abstract：:In patients with Alzheimer's disease (AD), postmortem and imaging studies have revealed early and prominent reductions in cerebral serotonin 2A (5-HT(2A)) receptors. To establish if this was due to a selective disease process of the serotonin system, we investigated the cerebral 5-HT(2A) receptor and the serotonin tra...

journal_title：Neurobiology of aging

authors： Marner L,Frokjaer VG,Kalbitzer J,Lehel S,Madsen K,Baaré WF,Knudsen GM,Hasselbalch SG

更新日期：2012-03-01 00:00:00

abstract：:Insertion and deletion variants (indels) within poly glycine tracts of fused in sarcoma (FUS) were initially reported as causative of disease in amyotrophic lateral sclerosis (ALS). Subsequent studies identified similar indels in controls and suggested that these indels may confer susceptibility to ALS. We aimed to el...

journal_title：Neurobiology of aging

authors： Rutherford NJ,Finch NA,DeJesus-Hernandez M,Crook RJ,Lomen-Hoerth C,Wszolek ZK,Uitti RJ,Graff-Radford NR,Rademakers R

更新日期：2012-02-01 00:00:00

abstract：:Striatal degeneration may contribute to cognitive impairment in older people. Here, we examine the relation of degeneration of the striatum and substructures to cognitive decline and dementia in subjects with a wide range of cognitive function. Data are from the prospective community-based Honolulu Asia Aging Study of...

journal_title：Neurobiology of aging

authors： de Jong LW,Wang Y,White LR,Yu B,van Buchem MA,Launer LJ

更新日期：2012-02-01 00:00:00

abstract：:Neuroimage measures from magnetic resonance (MR) imaging, such as cortical thickness, have been playing an increasingly important role in searching for biomarkers of Alzheimer's disease (AD). Recent studies show that, AD, mild cognitive impairment (MCI) and normal control (NC) can be distinguished with relatively high...

journal_title：Neurobiology of aging

authors： Li Y,Wang Y,Wu G,Shi F,Zhou L,Lin W,Shen D,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2012-02-01 00:00:00

abstract：:Prenatal ethanol exposure produces severe changes in brain, liver, and kidney through mechanisms involving growth factors. These molecules regulate survival, differentiation, maintenance, and connectivity of brain, liver, and kidney cells. Despite the abundant available data on the short and mid-lasting effects of eth...

journal_title：Neurobiology of aging

authors： Ceccanti M,Mancinelli R,Tirassa P,Laviola G,Rossi S,Romeo M,Fiore M

更新日期：2012-02-01 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF) supports the viability of midbrain dopamine (DA) neurons that degenerate in Parkinson's disease. Middle-aged, 12 month old, Gdnf heterozygous (Gdnf(+/-)) mice have diminished spontaneous locomotor activity and enhanced synaptosomal DA uptake compared with wild type mi...

journal_title：Neurobiology of aging

authors： Littrell OM,Pomerleau F,Huettl P,Surgener S,McGinty JF,Middaugh LD,Granholm AC,Gerhardt GA,Boger HA

更新日期：2012-02-01 00:00:00

abstract：:To better understand the role of insulin signaling in the development of Alzheimer's disease (AD), we utilized an animal model (intracerebroventricular injection of streptozotocin-ic-streptozotocin (STZ)) that displays insulin resistance only in the brain and exhibits AD pathology. In this model, deficits in hippocamp...

journal_title：Neurobiology of aging

authors： Shonesy BC,Thiruchelvam K,Parameshwaran K,Rahman EA,Karuppagounder SS,Huggins KW,Pinkert CA,Amin R,Dhanasekaran M,Suppiramaniam V

更新日期：2012-02-01 00:00:00

abstract：:Memory complaints of patients sometimes are not verified via standard cognitive testing. Acquisition of information in everyday life requires memorization in complex three-dimensional environments. The authors mimicked this with a photorealistic virtual environment (VE). Memory for verbal material and spatial scenery ...

journal_title：Neurobiology of aging

authors： Widmann CN,Beinhoff U,Riepe MW

更新日期：2012-02-01 00:00:00

abstract：:In the last decade, functional magnetic resonance imaging (fMRI) has emerged as a tool to study changes in brain function associated with a genetic risk for Alzheimer's disease (AD), with a particular focus on the effects of the APOE-ε4 allele. This review compiles the existing literature concerning the effects of APO...

journal_title：Neurobiology of aging

authors： Trachtenberg AJ,Filippini N,Mackay CE

更新日期：2012-02-01 00:00:00

abstract：:Iron overload may contribute to the risk of Alzheimer's disease (AD). In the Epistasis Project, with 1757 cases of AD and 6295 controls, we studied 4 variants in 2 genes of iron metabolism: hemochromatosis (HFE) C282Y and H63D, and transferrin (TF) C2 and -2G/A. We replicated the reported interaction between HFE 282Y ...

journal_title：Neurobiology of aging

authors： Lehmann DJ,Schuur M,Warden DR,Hammond N,Belbin O,Kölsch H,Lehmann MG,Wilcock GK,Brown K,Kehoe PG,Morris CM,Barker R,Coto E,Alvarez V,Deloukas P,Mateo I,Gwilliam R,Combarros O,Arias-Vásquez A,Aulchenko YS,Ikram MA

更新日期：2012-01-01 00:00:00

abstract：:Dopaminergic neurons in the substantia nigra produce dopamine for the nigrostriatal pathway that facilitates motor function. Postmortem examinations demonstrate an age-related loss of cells in the substantia nigra, with most of the cell loss focused on the dorsal substantia nigra compared with the ventral substantia n...

journal_title：Neurobiology of aging

authors： Vaillancourt DE,Spraker MB,Prodoehl J,Zhou XJ,Little DM

更新日期：2012-01-01 00:00:00

abstract：:Age-related decline in microstructural integrity of certain white matter tracts may explain cognitive decline associated with normal aging. Whole brain tractography and a clustering segmentation in 48 healthy individuals across the adult lifespan were used to examine: interhemispheric (corpus callosum), intrahemispher...

journal_title：Neurobiology of aging

authors： Voineskos AN,Rajji TK,Lobaugh NJ,Miranda D,Shenton ME,Kennedy JL,Pollock BG,Mulsant BH

更新日期：2012-01-01 00:00:00

abstract：:Increased susceptibility to energy imbalance and anorexia in old age are risk factors for malnutrition during aging, but the underlying mechanisms are not well understood. Here, we explored changes in taste-guided hedonic value ("liking") and motivation to obtain ("wanting") palatable foods as potential mediators of a...

journal_title：Neurobiology of aging

authors： Frutos MG,Pistell PJ,Ingram DK,Berthoud HR

更新日期：2012-01-01 00:00:00

abstract：:Paranodal axo-glial junctional complexes anchor the myelin sheath to the axon and breakdown of these complexes presumably facilitates demyelination. Myelin deterioration is also prominent in the aging central nervous system (CNS); however, the stability of the paranodal complexes in the aged CNS has not been examined....

journal_title：Neurobiology of aging

authors： Shepherd MN,Pomicter AD,Velazco CS,Henderson SC,Dupree JL

更新日期：2012-01-01 00:00:00

abstract：:In this study 5 patients with mild cognitive impairment (MCI) and 9 Alzheimer's disease (AD) patients underwent respectively 3- and 5-year follow-up positron emission tomography (PET) studies with N-methyl [(11)C] 2-(4-methylaminophenyl)-6-hydroxy-benzothiazole ((11)C-PIB) and (18)F-fluorodeoxyglucose ((18)F-FDG) to u...

journal_title：Neurobiology of aging

authors： Kadir A,Almkvist O,Forsberg A,Wall A,Engler H,Långström B,Nordberg A

更新日期：2012-01-01 00:00:00

abstract：:Telomere shortening is thought to contribute to premature senescence of satellite cells in Duchenne muscular dystrophy (DMD) muscle. Telomeric repeat binding factor-1 (TRF1) and poly (ADP-ribose) polymerase-1 (PARP1) are proteins known to modulate telomerase reverse transcriptase (TERT) activity, which controls telome...

journal_title：Neurobiology of aging

authors： Aguennouz M,Vita GL,Messina S,Cama A,Lanzano N,Ciranni A,Rodolico C,Di Giorgio RM,Vita G

更新日期：2011-12-01 00:00:00

abstract：:Many elderly individuals remain dementia-free throughout their life. However, some of these individuals exhibit Alzheimer disease neuropathology on autopsy, evidenced by neurofibrillary tangles (NFTs) in AD-specific brain regions. We conducted a genome-wide association study to identify genetic mechanisms that disting...

journal_title：Neurobiology of aging

authors： Kramer PL,Xu H,Woltjer RL,Westaway SK,Clark D,Erten-Lyons D,Kaye JA,Welsh-Bohmer KA,Troncoso JC,Markesbery WR,Petersen RC,Turner RS,Kukull WA,Bennett DA,Galasko D,Morris JC,Ott J

更新日期：2011-12-01 00:00:00

abstract：:The integrity of the white matter is critical in regulating efficient neuronal communication and maintaining cognitive function. Damage to brain white matter putatively contributes to age-related cognitive decline. There is a growing interest in animal models from which the mechanistic basis of white matter pathology ...

journal_title：Neurobiology of aging

authors： Coltman R,Spain A,Tsenkina Y,Fowler JH,Smith J,Scullion G,Allerhand M,Scott F,Kalaria RN,Ihara M,Daumas S,Deary IJ,Wood E,McCulloch J,Horsburgh K

更新日期：2011-12-01 00:00:00

abstract：:Since the introduction of amyloid imaging nearly 10 years ago, this technique has gained widespread use and acceptance. More recently, published reports have begun to appear in which amyloid imaging is used to detect the effects of antiamyloid therapies. This review will consider the issues involved in the use of amyl...

journal_title：Neurobiology of aging

authors： Klunk WE

更新日期：2011-12-01 00:00:00

abstract：:Alteration of key regulatory kinases may cause aberrant protein phosphorylation and aggregation in Alzheimer's disease (AD) and Parkinson's disease (PD). In this study, we investigated expression and phosphorylation status of glycogen synthase kinase 3 (GSK-3), protein kinase B (Akt) and tau protein in peripheral bloo...

journal_title：Neurobiology of aging

authors： Armentero MT,Sinforiani E,Ghezzi C,Bazzini E,Levandis G,Ambrosi G,Zangaglia R,Pacchetti C,Cereda C,Cova E,Basso E,Celi D,Martignoni E,Nappi G,Blandini F

更新日期：2011-12-01 00:00:00

abstract：:Age-related synaptic change is associated with the functional decline of the nervous system. It is unknown whether this synaptic change is the cause or the consequence of neuronal cell loss. We have addressed this question by examining mice genetically engineered to over- or underexpress neuregulin-1 (NRG1), a direct ...

journal_title：Neurobiology of aging

authors： Jin D,Ohlemiller KK,Lei D,Dong E,Role L,Ryugo DK,Bao J

更新日期：2011-12-01 00:00:00

abstract：:Dietary restriction (DR) extends lifespan in diverse organisms and, in animal and cellular models, can delay a range of aging-related diseases including Alzheimer's disease (AD). A better understanding of the mechanisms mediating these interactions, however, may reveal novel pathways involved in AD pathogenesis, and p...

journal_title：Neurobiology of aging

authors： Kerr F,Augustin H,Piper MD,Gandy C,Allen MJ,Lovestone S,Partridge L

更新日期：2011-11-01 00:00:00

abstract：:Supporting the hypothesis that proteasome dysfunction is involved in Parkinson's disease (PD), McNaught et al. (2004) reported that the systemic administration of the proteasome inhibitor Z-Ile-Glu(OtBu)-Ala-Leu-aldehyde (PSI) in rats led to the degeneration of the nigrostriatal pathway. However, several groups could ...

journal_title：Neurobiology of aging

authors： Shin M,Jan C,Jacquard C,Jarraya B,Callebert J,Launay JM,Hantraye P,Remy P,Palfi S,Brouillet E

更新日期：2011-11-01 00:00:00

abstract：:We evaluated the autophagy-lysosomal pathway and membrane fluidity in brain cells and mitochondrial membranes obtained from senescence-accelerated (SAMP(8)) and senescence-resistant (SAMR(1)) mice at 5 and 10 months of age. Moreover, we studied whether chronic treatment from age 1 to 10 months with melatonin stabilize...

journal_title：Neurobiology of aging

authors： García JJ,Piñol-Ripoll G,Martínez-Ballarín E,Fuentes-Broto L,Miana-Mena FJ,Venegas C,Caballero B,Escames G,Coto-Montes A,Acuña-Castroviejo D

更新日期：2011-11-01 00:00:00

abstract：:RACK1 (receptor for activated C-kinase 1), an anchoring protein that shuttles activated PKC to cellular membranes, plays an important role in PKC-mediated signal transduction pathways. A significant loss of RACK1 has been found in the brain of aging animals and Alzheimer's disease (AD) patients, which implicates the p...

journal_title：Neurobiology of aging

authors： Liu W,Dou F,Feng J,Yan Z

更新日期：2011-10-01 00:00:00

abstract：:The substantia innominata (SI) contains the nucleus basalis of Meynert, which provides the major cholinergic innervation to the entire cortical mantel and the amygdala; degeneration of nucleus basalis neurons correlates with cognitive decline in Alzheimer's disease (AD). However, whether SI atrophy occurs in individua...

journal_title：Neurobiology of aging

authors： George S,Mufson EJ,Leurgans S,Shah RC,Ferrari C,deToledo-Morrell L

更新日期：2011-10-01 00:00:00

abstract：:The apolipoprotein E (ApoE) ε4 allele has consistently been established as an Alzheimer's disease (AD) risk factor, but its pathological contribution to AD is obscure. Certain butyrylcholinesterase (BuChE) polymorphisms together with the ApoE ε4 allele synergistically increase the risk of AD. In addition, AD risk fact...

journal_title：Neurobiology of aging

authors： Darreh-Shori T,Modiri N,Blennow K,Baza S,Kamil C,Ahmed H,Andreasen N,Nordberg A

更新日期：2011-07-01 00:00:00

abstract：:Changes of performance monitoring during and after learning of stimulus-response (S-R) associations were examined in younger and older adults using event-related brain potentials (ERPs). To determine whether age-related differences in performance monitoring are attenuated when learning performance is equalized between...

journal_title：Neurobiology of aging

authors： Pietschmann M,Endrass T,Kathmann N

更新日期：2011-07-01 00:00:00

abstract：:Vascular risk factors have been implicated in the pathogenesis of vascular dementia and Alzheimer's disease. The identification of a novel vascular disease susceptibility locus at 9p21.3 has recently generated great interest. In the present study, we sought to determine whether a common genetic variant (tagged by rs13...

journal_title：Neurobiology of aging

authors： Emanuele E,Lista S,Ghidoni R,Binetti G,Cereda C,Benussi L,Maletta R,Bruni AC,Politi P

更新日期：2011-07-01 00:00:00

abstract：:The sporadic form of Alzheimer disease, late onset Alzheimer's disease (LOAD), is a multifactorial disease; a strong link between nutritional and genetic factors with normal aging and dementia is supported by studies on nutrition, metabolism, and neurodegeneration. Specifically, the involvement of homocysteine (HCY) a...

journal_title：Neurobiology of aging

authors： Fuso A,Scarpa S

更新日期：2011-07-01 00:00:00

abstract：:Humans carrying the prevalent rs9939609 A allele of the fat mass and obesity-associated (FTO) gene are more susceptible to developing obesity than noncarries. Recently, polymorphisms in the FTO gene of elderly subjects have also been linked to a reduced volume in the frontal lobe as well as increased risk for incident...

journal_title：Neurobiology of aging

authors： Benedict C,Jacobsson JA,Rönnemaa E,Sällman-Almén M,Brooks S,Schultes B,Fredriksson R,Lannfelt L,Kilander L,Schiöth HB

更新日期：2011-06-01 00:00:00

abstract：:We examined the interaction of brain atrophy and white matter lesions (WML) with cognitive functioning in 605 patients (mean age, 58±10; 76% men) with atherosclerotic disease from the Second Manifestations of ARTerial disease-MR substudy (SMART-MR study). Automated brain segmentation was used to quantify volumes of br...

journal_title：Neurobiology of aging

authors： Muller M,Appelman AP,van der Graaf Y,Vincken KL,Mali WP,Geerlings MI

更新日期：2011-05-01 00:00:00

abstract：:The overall goal was to identify patterns of brain atrophy associated with cognitive impairment and future cognitive decline in non-demented elders. Seventy-one participants were studied with structural MRI and neuropsychological testing at baseline and 1-year follow-up. Deformation-based morphometry was used to exami...

journal_title：Neurobiology of aging

authors： Cardenas VA,Chao LL,Studholme C,Yaffe K,Miller BL,Madison C,Buckley ST,Mungas D,Schuff N,Weiner MW

更新日期：2011-04-01 00:00:00

abstract：:The Tachykinin Receptor 2 (TACR2) located at chromosome 10q21.3 belongs to a class of receptors that bind members of the tachykinin neurotransmitter family. The TACR2 binds neurokinin A, also known as substance K, and is expressed in distinct parts of the human brain. Functionally, the TACR2 has been implicated in str...

journal_title：Neurobiology of aging

authors： Friedrich P,Feulner TM,Laws SM,Eckart K,Perneczky R,Kurz A,Förstl H,Riemenschneider M

更新日期：2011-03-01 00:00:00

abstract：:Recently, two large, and independent genome wide association studies of late-onset Alzheimer's disease (AD) established association with the same rs11136000 variation in the clusterin (CLU) gene. In addition, one variation, rs3851179, in the phosphatidylinositol binding clathrin assembly protein (PICALM) gene and one ...

journal_title：Neurobiology of aging

authors： Mengel-From J,Christensen K,McGue M,Christiansen L

更新日期：2011-03-01 00:00:00

abstract：:To determine whether polymorphisms in the microtubule-associated protein tau (MAPT) and/or glycogen synthase kinase-3β (GSK3β) genes underpin susceptibility to Parkinson's disease (PD), we conducted a case-control association study in a Greek cohort of 196 PD cases and 163 healthy controls. In our study, the MAPT H1 h...

journal_title：Neurobiology of aging

authors： Kalinderi K,Fidani L,Katsarou Z,Clarimón J,Bostantjopoulou S,Kotsis A

更新日期：2011-03-01 00:00:00

abstract：:The H1 MAPT haplotype in the 17q21 chromosomal region has been associated with several neurodegenerative diseases. Some reports have suggested that there is an association between genetic variants within the H1 haplotype with Parkinson's disease (PD), progressive supranuclear palsy (PSP) and corticobasal degeneration ...

journal_title：Neurobiology of aging

authors： Ezquerra M,Pastor P,Gaig C,Vidal-Taboada JM,Cruchaga C,Muñoz E,Martí MJ,Valldeoriola F,Aguilar M,Calopa M,Hernandez-Vara J,Tolosa E

更新日期：2011-03-01 00:00:00

abstract：:Activated microglia are instrumental to neurodegeneration in Parkinson's disease (PD). Fractalkine, as an exclusive ligand for CX3CR1 expressed on microglia, has recently been reported to be released out by neurons, and induce microglial activation as a neuron-to-glia signal in the spinal cord. However, the role of fr...

journal_title：Neurobiology of aging

authors： Shan S,Hong-Min T,Yi F,Jun-Peng G,Yue F,Yan-Hong T,Yun-Ke Y,Wen-Wei L,Xiang-Yu W,Jun M,Guo-Hua W,Ya-Ling H,Hua-Wei L,Ding-Fang C

更新日期：2011-03-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a devastating disorder involving loss of movement due to degeneration of motor neurons. Studies suggest that in ALS axonal dysfunction precedes the death of motor neurons. Pathologically, ALS is characterized by neurofilamentous swellings (spheroids) within the axons of motor neu...

journal_title：Neurobiology of aging

authors： King AE,Dickson TC,Blizzard CA,Woodhouse A,Foster SS,Chung RS,Vickers JC

更新日期：2011-03-01 00:00:00

abstract：:Psychotic symptoms occur in approximately 40% of subjects with Alzheimer disease (AD with psychosis; AD + P) and identify a subgroup with more rapid cognitive decline. We evaluated in 867 AD subjects the association of AD + P with genes which may modify the pathological process via effects on the accumulation of amylo...

journal_title：Neurobiology of aging

authors： DeMichele-Sweet MA,Klei L,Devlin B,Ferrell RE,Weamer EA,Emanuel JE,Lopez OL,Sweet RA

更新日期：2011-03-01 00:00:00